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Test Compendium

Test Name

  • ROMA (Risk of Ovarian Malignancy Algorithm)

Test Code

  • 2642

Test Synonym


Gender Restriction

  • Female

Minimum Volume

  • 2 mL

Specimen Type

  • Serum

Primary Container

  • Serum Separator Tube, Plain Red Top Tube

Transport Temp

  • Refrigerated


  • 2 days

Specimen Requirements

  • 2 mL serum from an SST or Red Top Tube.

Specimen Retention

  • The Risk for Ovarian Malignancy Algorithm (ROMA) test is intended to aid in assessing whether a premenopausal or postmenopausal woman who presents with an ovarian adnexal mass is at high or low likelihood of finding malignancy on surgery. ROMA is indicated for women who meet the following criteria: over age 18; ovarian adnexal mass present for which surgery is planned, and not yet referred to an oncologist. ROMA must be interpreted in conjunction with an independent clinical and radiological assessment. The test is not intended as a screening or stand-alone diagnostic assay. HE4 and CA125 values obtained with different assay methods or kits cannot be used interchangeably.